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Chrysin upregulates fatty acid transport genes Cd36 and Cpt1b, reduces long-chain fatty acid accumulation, promotes mitochondrial fatty acid oxidation, and simultaneously restores the expression of genes related to mitochondrial oxidative phosphorylation and TCA, increases total adenylate concentration, improves energy production, and ameliorates right ventricular dysfunction in PAH rat models (Kobayashi et al., 2022)

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Novel multicompartmental carriers were developed by assembling liposomes with a protective poly (dopamine) shell and a PEG layer, along with temperature-sensitive poly (N-isopropylacrylamide-co-acrylic acid) microgels

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